Karen M. Caggiano of Plymouth, age 73, September 17, 2022. Beloved wife of Edward. Loving mother of Wendy (Nick) Lyon, Kristy (Bryan) Wilson, and Rebecca (Don) Lavine. Dearest grandmother of Jake and Lauren, Kayla, Reese and Brie, Ashley and Alivia. Great grandmother of Jett Mychael. Sister of Patty (Charlie) Tringali, Tom O'Brien and the late Frankie O'Brien. Also survived by many nieces, nephews, and cousins. Karen O’Brien was born on October 14, 1948 in Detroit, Michigan, she graduated from Regina High School and Mercy School of Nursing. She worked as a nurse for many years; providing care and compassion to a countless number of patients, family, and friends. She loved horses, maintaining her beautiful flowers, and spending time up north enjoying the beauty of Lake Huron with her family and friends. Karen’s family will receive visitors Sunday, September 25, 2022 at 11:00 am until her Memorial Service at 2:00 pm at R.G. & G.R. Harris Funeral Home, 15451 Farmington Rd., Livonia, MI 48154. There will be a luncheon immediately following the service. Please share a memory of Karen on her Tribute Wall.